ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A |
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Authors: | Merle Nicolas Féraud Olivier Gilquin Benoit Hubstenberger Arnaud Kieffer-Jacquinot Sylvie Assard Nicole Bennaceur-Griscelli Annelise Honnorat Jérôme Baudier Jacques |
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Affiliation: | INSERM Unité 1038 and INSERM U873, 17 rue des Martyrs, 38054 Grenoble, France. |
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Abstract: | Here we report on the identification of a human pluripotent embryonic stem cell (hESC) specific mitochondrial protein that is re-expressed in cancer cells, ATAD3B. ATAD3B belongs to the AAA+ ATPase ATAD3 protein family of mitochondrial proteins specific to multicellular eukaryotes. Using loss- and gain-of-function approaches, we show that ATAD3B associates with the ubiquitous ATAD3A species, negatively regulates the interaction of ATAD3A with matrix nucleoid complexes and contributes to a mitochondria fragmentation phenotype. We conclude that ATAD3B is a negative regulator of ATAD3A and may function as an adaptor of mitochondrial homeostasis and metabolism in hESCs and cancer cells. |
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