Antimicrobial peptides: clinical relevance and therapeutic implications |
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Authors: | Pinheiro da Silva Fabiano Machado Marcel Cerqueira César |
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Affiliation: | Emergency Medicine Department, University of Sao Paulo, Brazil. pinheirofabiano@hotmail.com |
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Abstract: | Antimicrobial peptides (AMPs) are molecules that provide protection against environmental pathogens, acting against a large number of microorganisms, including bacteria, fungi, yeast, virus and others. Two major groups of antimicrobial peptides are found in humans: cathelicidins and defensins. Recently, several studies have furnished information that besides their role in infection diseases, antimicrobial peptides play a role in diseases as diverse as inflammatory disorders, autoimmunity and cancer. Here, we discuss the role of antimicrobial peptides and vitamin D have in such complex diseases and propose their use should be more explored in the diagnosis and treatment of such conditions. |
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Keywords: | Cathelicidins Defensins Vitamin D Autoimmunity, Infection and cancer |
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