Positive and negative signaling mechanisms in the regulation of photoreceptor induction in the developingDrosophila retina |
| |
Authors: | Daisuke Yamamoto |
| |
Institution: | (1) Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo, Japan |
| |
Abstract: | An ommatidium of aDrosophila compound eye contains eight photoreceptor cells, R1–R8. The fates of the photoreceptors are determined exclusively by inductive
interactions between neuronal precursors in the cell cluster from which the ommatidium is formed. R7 induction has been extensively
analysed at the molecular level. Activation of a membrane receptor tyrosine kinase (Sevenless) in the R7 precursor by a ligand
(Bride of sevenless) present on the surface of R8 triggers a transduction cascade mediated by Ras, establishing the R7 fate
of this cell. Other Sev-expressing cells are prevented from taking on the R7 fate by several different mechanisms. Pokkuri-mediated
repression represents one such regulatory mechanism. The positive and negative signaling pathways operating in the fate determination
of other photoreceptor cells are also discussed. |
| |
Keywords: | cell-cell communication compound eye developmental genes fate determination neurogenesis |
本文献已被 SpringerLink 等数据库收录! |