Discovery and evaluation of potent, tyrosine-based alpha4beta1 integrin antagonists |
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| Authors: | Archibald S C Head J C Gozzard N Howat D W Parton T A Porter J R Robinson M K Shock A Warrellow G J Abraham W M |
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| Affiliation: | Celltech Chiroscience, Slough, UK. |
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| Abstract: | Using disulphide cysteine-based inhibitors as lead structures, this communication describes our strategy for identifying more stable, potent antagonists of the alpha4beta1 integrin. These studies ultimately discovered potent, low molecular weight inhibitors based on D-thioproline-L-tyrosine. |
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