| 转酮酶在癌症中的作用及其机制研究进展 |
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| 引用本文： | 秦兆宇,贺福初,钟凡.转酮酶在癌症中的作用及其机制研究进展[J].生物技术通讯,2013(6):861-864. |
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| 作者姓名： | 秦兆宇 贺福初 钟凡 |
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| 作者单位： | [1]复旦大学生命科学学院与生物医学研究院,上海200032 [2]军事医学科学院放射与辐射医学研究所,北京100850 |
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| 基金项目： | 国家自然科学基金青年项目（31000379） |
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| 摘 要： | 肿瘤细胞的一大重要特征是代谢水平的改变。戊糖磷酸途径作为细胞产生NADPH和五碳糖的主要通路，在肿瘤发生发展过程中发挥着重要功能。转酮酶是戊糖磷酸途径中的关键酶之一，越来越多的研究表明其与癌症病人预后具有显著相关性。作为肿瘤诊断、治疗的潜在靶标，转酮酶具有重要的研究价值。我们就目前癌症研究中对转酮酶的研究进展做简要综述。
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| 关 键 词： | 转酮酶 戊糖磷酸途径 肿瘤 |
Progress of the Functional and Mechanism Research of Transketolase in Caner |
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| QIN Zhao-Yu,HE Fu-Chu,ZHONG Fan.Progress of the Functional and Mechanism Research of Transketolase in Caner[J].Letters in Biotechnology,2013(6):861-864. |
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| Authors: | QIN Zhao-Yu HE Fu-Chu ZHONG Fan |
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| Institution: | 1. School of Life Sciences, Institute of Biomedical Sciences, Fudan University, Shanghai 200032; 2. Beijing Institute of Radiation Medicine, Beijing 100850; China) |
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| Abstract: | Metabolic switch is one of the hallmarks of cancer cells. Pentose phosphate pathway, as an important metabolic pathway for generation of NADPH and for fermentation of five-carbon sugars, plays a crucial role in tumor progression. Transketolase is one of the key enzymes in pentose phosphate pathway. The correlation between transketolase and cancer has been proved in more and more studies. It is considered as a potential biomarker for cancer diagnosis and therapy. |
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| Keywords: | transketolase pentose phosphate pathway cancer |
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