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| 猪链球菌2型疫苗研究进展 | |
| 引用本文： | 郑继平,郭桂英,韦双双,周海龙,张兆山. 猪链球菌2型疫苗研究进展[J]. 生物技术通讯, 2006, 17(5): 826-829 |
| 作者姓名： | 郑继平 郭桂英 韦双双 周海龙 张兆山 |
| 作者单位： | 1. 海南大学,生命科学与农学院,海南,海口,570228 2. 海南大学,教务处,海南,海口,570228 3. 军事医学科学院,生物工程研究所,北京,100071 |
| 基金项目： | 海口市农业局农业科技三项资助项目(2006007) |
| 摘 要： | 猪链球菌2型可引起人、猪急性败血型、脑膜炎型和关节炎型等传染病,致死率极高,是近年来致病性最强、危害性最大的猪链球菌类型之一。目前因该菌的致病机理不清、抗原类型复杂,限制了疫苗研究的顺利进行。当前在研的猪链球菌2型疫苗类型有死疫苗、弱毒苗、蛋白亚单位疫苗等。 |
| 关 键 词： | 猪链球菌2型 抗原 疫苗 |
| 文章编号： | 1009-0002(2006)05-0826-04 |
| 收稿时间： | 2005-12-01 |
| 修稿时间： | 2005-12-01 |
Progress Toward the Development of a Vaccine Against Streptococcus suis Capsular Type2 |
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| ZHENG Ji-ping,GUO Gui-ying,WEI Shuang-shuang,ZHOU Hai-long,ZHANG Zhao-shan. Progress Toward the Development of a Vaccine Against Streptococcus suis Capsular Type2[J]. Letters in Biotechnology, 2006, 17(5): 826-829 | |
| Authors: | ZHENG Ji-ping GUO Gui-ying WEI Shuang-shuang ZHOU Hai-long ZHANG Zhao-shan |
| Affiliation: | 1. a. College of Life Science and Agriculture; b. Academic Affairs Office; Hainan University, Haikou 570228; 2. Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071; China |
| Abstract: | Streptococcus suis capsular type 2 is an important worldwide swine pathogen which causes sepsis, meningitis, arthritis and other serious infections in pigs, and also as a zoonotic agent in humans who occupationally exposed to pigs or pig products. As the most prevalent and the most virulent serotype of the 35 reported Streptococcus suis serotypes in diseased animals, knowledge on the pathogenesis of the infection is poorly understood and the virulence-factor antigens is limited. To date several candidate vaccines against Streptococcus suis capsular type 2, that is killed vaccine, live avirulent vaccine and protein subunit vaccine have been proposed, but no effective vaccine is available. |
| Keywords: | Streptococcus suis capsular type 2 antigen vaccine |
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