Localization by in situ hybridization of the coagulation factor IX gene and of two polymorphic DNA probes with respect to the fragile X site |
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| Authors: | M G Mattei M A Baeteman R Heilig I Oberlé K Davies J L Mandel J F Mattei |
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| Institution: | (1) U 242 INSERM and Centre de Génétique Médicale, Hôpital d'Enfants de la Timone, 13385 Marseille Cedex 5, France;(2) Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS Faculté de Médecine, U. 184 INSERM de Biologie Moléculaire et Génie Génétique, 11 rue Humann, 67085 Strasbourg Cedex, France;(3) Molecular Genetic Group, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, OX3 9DU Oxford, UK |
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| Abstract: | Summary The coagulation factor IX gene and two other polymorphic loci corresponding to DNA probes 52 A and St 14 have been previously localized in the q27 to qter region of the human X chromosome. In order to study their localization with respect to the fragile site at Xq27-28, we have hybridized the three DNA probes to metaphase chromosomes of a boy with fragile X mental retardation. We show that probe 52A is located in the proximal part of the Xq27 band, while the coagulation factor IX gene is on the distal part of this band, but proximal to the fragile site. The very polymorphic St 14 probe is located in the distal part of the Xq28 band, on the other side of the fragile site. |
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