| 蛋白质药物口服的研究进展 |
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| 引用本文： | 惠二京,尹帮旗,李招发. 蛋白质药物口服的研究进展[J]. 生物技术通报, 2011, 0(6) |
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| 作者姓名： | 惠二京 尹帮旗 李招发 |
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| 作者单位： | 1. 华侨大学分子药物学研究所,泉州,362021
2. 华侨大学分子药物学研究所,泉州,362021;华侨大学分子药物教育部工程研究中心,泉州,362021 |
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| 基金项目： | 福建省自然科学基金，福建省重点项目 |
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| 摘 要： | 蛋白质药物口服给药系统因其给药方便、顺应性好,逐渐成为一种最有前景的给药方式.从提高蛋白质药物生物利用度入手,综述采用结构修饰、吸收促进剂、酶抑制剂、结肠定位释药、脉冲式药物给药系统和受体介导靶向载体系统等方式,均可大大提高蛋白质药物的口服生物利用度和在胃肠道中的稳定性.
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| 关 键 词： | 蛋白药物 给药途径 口服给药 |
Research Development of Oral Peptide and Protein Drugs |
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| Hui Erjing,Yin Bangqi,Li Zhaofa. Research Development of Oral Peptide and Protein Drugs[J]. Biotechnology Bulletin, 2011, 0(6) |
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| Authors: | Hui Erjing Yin Bangqi Li Zhaofa |
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| Affiliation: | Hui Erjing~1 Yin Bangqi~1 Li Zhaofa~(1,2) (1 Institute of Molecular Medicine,Huaqiao University,Quanzhou 362021,2 Molecular Medicine Engineering Research Center of the Ministry of Education,Quanzhou 362021) |
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| Abstract: | Peptide and protein drugs for oral administration because of its easy to take,attractive compliance,has increasingly become one of the most promising delivery system.This review,from the angle of improving the bioavailability of protein drug,discussed the use of structural modification,absorption enhancers,enzyme inhibitors,colon-specific targeting drug absorption,pulsatile drug delivery system,receptor-mediated protein absorption system can be greatly improved the oral bioavailability and the stability of ... |
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| Keywords: | Protein drugs Delivery approach Oral drugs |
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