Anti-insulin receptor serum mimics the developmental role of insulin in mouse mammary explants |
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| Authors: | K R Nicholas Y J Topper |
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| Affiliation: | Laboratory of Biochemistry and Metabolism National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases National Institutes of Health, Bethesda, Maryland 20205 USA |
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| Abstract: | A number of growth factors can maintain hormonally-responsive epithelium in murine mammary explants as well as insulin, but only insulin can promote the synthesis of casein and alpha-lactalbumin, in the presence of glucocorticoid and prolactin. Anti-insulin receptor serum can elicit these effects of insulin on milk protein gene expression. The anti-serum is unique in its ability to mimic the developmental role of insulin in murine mammary epithelium. |
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| Keywords: | I insulin F hydrocortisone P prolactin BSA bovine serum albumin ARS anti-insulin receptor serum CS control serum AIB α-aminoisobutyric acid casein mRNA |
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