Ketone body transport in renal brush border membrane vesicles |
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Authors: | Maria Luisa Garcia Jesus Benavides Fernando Valdivieso |
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Affiliation: | Departmento de Bioquímica y Biología Molecular, Centro de Biología Molecular, Facultad de Ciencias, Universidad Autónoma, Madrid-34 Spain |
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Abstract: | Ketone body uptake by renal brush border vesicles has been investigated. Ketone bodies enter into the brush border vesicles by a carrier-mediated process. The uptake is dependent on an Na+ gradient ([Na+]outside > [Na+]inside) and is electroneutral. The uptake is transport into an osmotically active space and not a binding artifact as indicated by the effect of increasing the medium osmolarity. A pH gradient (alkaline inside) also stimulates the ketone body uptake. Acetoacetate and 3-hydroxybutyrate share the same carrier as demonstrated by the accelerated exchange diffusion and mutual inhibitory effects. |
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Keywords: | Ketone body Transport Renal brush border |
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