KAI1/CD82 suppresses hepatocyte growth factor- induced migration of hepatoma cells via upregulation of Sprouty2 |
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Authors: | MU ZhenBin WANG Hua ZHANG Jing LI QingFang WANG LiSheng & GUO XiaoZhong |
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Affiliation: | State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. |
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Abstract: | We conducted a study concerning the suppressive mechanism of KAI1/CD82 on hepatoma cell metastasis.Hepatocyte growth factor(HGF)induces the migration of hepatoma cells through activation of cellular sphingosine kinase 1(SphK1).Adenovirus-mediated gene transfer of KAI1(Ad-KAI1)downregulates the SphK1 expression and suppresses the HGF-induced migration of SMMC-7721 human hepatocellcular carcinoma cells.Overexpression of KAI1/CD82 significantly elevates Sprouty2 at the protein level.Ablation of Sprouty2 with RNA interference can block the KAI1/CD82-induced suppression of hepatoma cell migration and downregulation of SphK1 expression.It is demonstrated that KAI1/CD82 suppresses HGF-induced migration of hepatoma cells via upregulation of Sprouty2. |
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Keywords: | KAI1/CD82 Sprouty2 migration hepatocyte growth factor |
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