| 大鼠延髓腹外侧部微量注射心房钠尿肽的心血管效应 |
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| 引用本文： | 骆鸿,赵工.大鼠延髓腹外侧部微量注射心房钠尿肽的心血管效应[J].生理学报,1992,44(5):515-519. |
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| 作者姓名： | 骆鸿 赵工 |
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| 作者单位： | 河北医学院基础医学研究所生理室，河北医学院基础医学研究所生理室，河北医学院基础医学研究所生理室 石家庄 050017，石家庄 050017，石家庄 050017 |
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| 摘 要： | 在麻醉大鼠观察了延髓腹外侧部的谷氨酸敏感区(GSA)应用ANP对血压和心率的影响。在GSA应用α-hANP,血压和心率明显降低。低浓度的APⅢ(10~(-6)mol/L)仅引起血压减低而不伴有心率减慢效应,而高浓度的APⅢ对血压和心率均有抑制效应。这些结果提示,ANP可能具有抑制延髓交感中枢作用并可能作为动脉压力感受器中枢通路的一种化学递质或调质。
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| 关 键 词： | 心房钠尿肽 交感中枢 延髓 |
CARDIOVASCULAR RESPONSES TO MICROINJECTION OF ATRIAL NATRIURETIC PEPTIDE INTO VENTROLATERAL MEDULLA OF RAT |
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| LUO HONG,ZHAO GONG,HE RUI-RONG,HO SHIU-YONG.CARDIOVASCULAR RESPONSES TO MICROINJECTION OF ATRIAL NATRIURETIC PEPTIDE INTO VENTROLATERAL MEDULLA OF RAT[J].Acta Physiologica Sinica,1992,44(5):515-519. |
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| Authors: | LUO HONG ZHAO GONG HE RUI-RONG HO SHIU-YONG |
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| Institution: | Department of Physiology, Institute of Basic Medicine, Hebei Medical College, Shijiazhuang. |
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| Abstract: | Application of atrial natriuretic peptides (alpha-ANP and AP III) to glutamate sensitive area of ventrolateral medulla produced a dose-dependent decrease in MAP and HR in anesthetized rats. Lower dosage of AP III induced hypotension without bradycardia, whereas the higher dosage of AP III decreased both blood pressure and heart rate. The results suggested that ANP may inhibit the medullary sympathetic center. |
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| Keywords: | ventrolateral medulla atrial natriuretic peptide sympathetic center baroreceptor reflex |
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