CELL KINETICS OF GROWTH CARTILAGE IN THE RAT TIBIA I. MEASUREMENTS IN YOUNG MALE RATS |
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| Authors: | K. V. R. Walker N. F. Kember |
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| Affiliation: | Department of Medical Physics, Royal Free Hospital School of Medicine, London |
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| Abstract: | Cell kinetic parameters for the proximal growth plate of the tibia have been measured in young rats. Analysis of a pulse labelled mitosis study gave values of 55 ± 40 hr for the cycle time and 6.5 ± 0.3 hr for the synthesis time in 6-week-old rats. The results of a simulated continuous labelling experiment agreed with this data and provided further information on the size and proliferation rate of the stem cell zone. Diurnal variations in mitotic index and labelling index in the tissue have been investigated. |
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