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Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction
Authors:Clara Albiñana  Jakob Grove  John J. McGrath  Esben Agerbo  Naomi R. Wray  Cynthia M. Bulik  Merete Nordentoft  David M. Hougaard  Thomas Werge  Anders D. Børglum  Preben Bo Mortensen  Florian Privé  Bjarni J. Vilhjálmsson
Affiliation:1. The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark;2. National Centre for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark;3. Department of Biomedicine and Center for Integrative Sequencing, iSEQ, Aarhus University, 8000 Aarhus C, Denmark;4. Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Brisbane, QLD 4076, Australia;5. Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia;6. Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia;7. Center for Genomics and Personalized Medicine, CGPM, Aarhus University, 8000 Aarhus C, Denmark;8. Bioinformatics Research Centre, Aarhus University, 8000 Aarhus C, Denmark;9. Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA;10. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden;11. Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA;12. Copenhagen University Hospital, Mental Health Centre Copenhagen Mental Health Services in the Capital Region of Denmark, 2100 Copenhagen Ø, Denmark;13. Department of Clinical Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark;14. Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, 2300 Copenhagen S, Denmark;15. Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, 4000 Roskilde, Denmark;16. Lundbeck Foundation GeoGenetics Centre, GLOBE Institute, University of Copenhagen, 1350 Copenhagen K, Denmark
Abstract:
Keywords:PRS  complex traits  genetic prediction  polygenic risk scores  meta-analysis  psychiatric disorders
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