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Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations
Authors:Alicia R Martin  Elizabeth G Atkinson  Sinéad B Chapman  Anne Stevenson  Rocky E Stroud  Tamrat Abebe  Dickens Akena  Melkam Alemayehu  Fred K Ashaba  Lukoye Atwoli  Tera Bowers  Lori B Chibnik  Mark J Daly  Timothy DeSmet  Sheila Dodge  Abebaw Fekadu  Steven Ferriera  Bizu Gelaye  Zukiswa Zingela
Institution:1. Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA;2. Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;3. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;4. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA;5. Department of Microbiology, Immunology, and Parasitology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia;6. Department of Psychiatry, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda;7. Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia;8. Department of Immunology & Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda;9. Department of Mental Health, School of Medicine, Moi University College of Health Sciences, Eldoret, Kenya;10. Broad Genomics, Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, MA 02141, USA;11. Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA;12. Institute for Molecular Medicine Finland, Helsinki 00014, Finland;13. Centre for Innovative Drug Development & Therapeutic Trials for Africa, Addis Ababa University, Addis Ababa, Ethiopia;14. Department of Mental Health, Moi Teaching and Referral Hospital, Eldoret, Kenya;15. Department of Immunology, School of Medicine, Moi University College of Health Sciences, Eldoret, Kenya;16. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa;17. Neurosciences Unit, Clinical Department, KEMRI-Wellcome Trust Research Programme-Coast, Kilifi, Kenya;18. Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK;19. Department of Pharmacology and Toxicology, School of Medicine, Moi University College of Health Sciences, Eldoret, Kenya;20. SA MRC Human Genetics Research Unit, Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa;21. Gencove, Inc., New York, NY 10016, USA;22. SA MRC Genomic and Precision Medicine Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa;23. SA MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town and Neuroscience Institute, Cape Town, South Africa;24. Department of Psychiatry and Human Behavioral Sciences, Walter Sisulu University, Mthatha, South Africa
Abstract:
Keywords:low-coverage sequencing  GWAS  GWAS arrays  whole-genome sequencing  cost comparison  study design  Africa
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