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Impaired cholesterol efflux in retinal pigment epithelium of individuals with juvenile macular degeneration
Authors:Yi-Ting Tsai  Yao Li  Joseph Ryu  Pei-Yin Su  Chia-Hua Cheng  Wen-Hsuan Wu  Yong-Shi Li  Peter MJ Quinn  Kam W Leong  Stephen H Tsang
Institution:1. Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA;2. Jonas Children’s Vision Care and the Bernard & Shirlee Brown Glaucoma Laboratory, Department of Ophthalmology, Columbia Stem Cell Initiative, Columbia University, New York, NY 10032, USA;3. Edward S. Harkness Eye Institute, New York-Presbyterian Hospital, New York, NY 10032, USA;4. Department of Pathology & Cell Biology, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Abstract:
Keywords:age-related macular degeneration  Doyne honeycomb destrophy  DHRD  cholesterol efflux  drusen  RPE  CRISPR  isogenic  EGFR signaling  unfolded protein response  lipid accumulation
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