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Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals
Authors:Jack A Kosmicki  Julie E Horowitz  Nilanjana Banerjee  Rouel Lanche  Anthony Marcketta  Evan Maxwell  Xiaodong Bai  Dylan Sun  Joshua D Backman  Deepika Sharma  Fabricio SP Kury  Hyun M Kang  Colm O’Dushlaine  Ashish Yadav  Adam J Mansfield  Alexander H Li  Kyoko Watanabe  Lauren Gurski  Manuel AR Ferreira
Institution:1. Regeneron Genetics Center, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA;2. Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, UK;3. Biogen, 300 Binney Street, Cambridge, MA 02142, USA;4. Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA;5. Bristol Myers Squibb, Route 206 and Province Line Road, Princeton, NJ 08543, USA;6. Takeda California, Inc., 9625 Towne Centre Drive, San Diego, CA 92121, USA;7. AbbVie, Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA;8. Pfizer, Inc., 1 Portland Street, Cambridge, MA 02139, USA;9. Geisinger, Danville, PA 17822, USA;10. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;11. Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA;12. Department of Genetics and Development, Columbia University, New York, NY 10032, USA;13. Division of Nephrology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA;14. Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK;15. MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK;16. Genomics England, London EC1M 6BQ, UK;17. Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, Teviot Place, Edinburgh EH8 9AG, UK;18. William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK;19. Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK;20. Intensive Care Unit, Royal Infirmary of Edinburgh, 54 Little France Drive, Edinburgh EH16 5SA, UK;21. Lady Davis Institute, Jewish General Hospital, Montréal, QC H3T 1E2, Canada;22. Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, QC H3A 0G4, Canada;23. Department of Human Genetics, McGill University, Montréal, QC H3A 0G4, Canada;24. Kyoto-McGill International Collaborative School in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan;25. Canadian Centre for Computational Genomics, McGill University, Montréal, QC H3A 0G4, Canada;26. Department of Twins Research, King’s College London, London WC2R 2LS, UK
Abstract:
Keywords:exome sequencing  rare variants  COVID-19  genetics  association  SARS-CoV-2  burden  TLR7  ZC3HAV1
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