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A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits
Authors:Mingxuan Cai  Jiashun Xiao  Shunkang Zhang  Xiang Wan  Hongyu Zhao  Gang Chen  Can Yang
Institution:1. Guangzhou HKUST Fok Ying Tung Research Institute, Guangzhou 511458, China;2. Department of Mathematics, The Hong Kong University of Science and Technology, Hong Kong SAR, China;3. Shenzhen Research Institute of Big Data, Shenzhen 518172, China;4. Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha 410083, China;5. SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai 201111, China;6. Department of Biostatistics, Yale School of Public Health, New Haven, CT 06510, USA
Abstract:
Keywords:polygenic risk score  cross-population  ancestry  GWAS  UK Biobankcross-population
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