Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc |
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Authors: | Helen E Gruber Jane A Ingram Gretchen L Hoelscher Natalia Zinchenko Edward N Hanley and Yubo Sun |
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Institution: | (1) Department of Orthopedic Surgery, Carolinas Medical Center, PO Box 32861, 28232 Charlotte, NC, USA |
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Abstract: | Introduction Asporin, also known as periodontal ligament-associated protein 1 (PLAP1), is a member of the family of small leucine-rich
proteoglycan (SLRP) family. It is present within the cartilage extracellular matrix (ECM), and is reported to have a genetic
association with osteoarthritis. Its D14 allele has recently been found to be associated with lumbar disc degeneration in
Asian subjects. There have been no studies, however, of this gene's normal immunohistochemical localization within the human
intervertebral disc, or of expression levels in Caucasian individuals with disc degeneration. |
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