基质金属蛋白酶-2,-9在子宫腺肌病的表达

目的　探讨基质金属蛋白酶 2 , 9(MMP 2 , 9)在子宫腺肌病的表达及与发病机制的关系。方法　采用免疫组织化学SP法对 2 8例子宫腺肌病 (疾病组 )异位及原位内膜 ,35例子宫肌瘤 (对照组 )原位内膜中MMP 2 , 9的表达进行测定 ,应用图像分析系统分析MMP 2 , 9平均光密度值。结果　MMP 2 , 9于两组原位内膜中表达均呈月经周期依赖性 ,分泌期的表达强度高于增生期 (P <0 0 5 ) ;于疾病组异位内膜中表达无周期性显著差异 (P >0 0 5 )。疾病组内增生期异位内膜MMP 2 , 9的表达强度高于原位内膜 (P <0 0 5 )。疾病组整个月经周期中 ,MMP 2 , 9于原位及异位内膜的表达皆持续明显高于对照组 (P <0 0 5 )。结论　研究显示子宫腺肌病原位和异位内膜MMP 2 , 9的过度表达可能与其发病机制有关

EXPRESSION OF MATRIX METALLOPROTEINASE-2,-9 IN PATIENTS WITH ADENOMYOSIS

Objective To investigate the expression of MMP 2, 9 in adenomyosis and its relation with the pathogenesis MethodEndometrium specimens were obtained from 35 patients with hysteromyoma (controls) and 28 with adenomyosis. MMP 2, 9 were detected by immunohistochemical SP staining A computerized image analysis system was used to analyse the expression of MMP 2, 9 ResultThe expression of MMP 2, 9 showed phase dependent changes in the eutopic endometrium of both groups, higher in the secretory phase than in the proliferative phase ( P <0 05) In the ectopic endometrium with adenomyosis, the expression was similar in both phases ( P >0 05), but significantly higher than that in the eutopic endometrium with adenomyosis in the proliferative phase( P <0 05) The expression of MMP 2, 9 in the ectopic and eutopic endometrium with adenomyosis was persistently stronger than that of the controls throughout the menstrual cycle( P <0 05) ConclusionOverexpression of MMP 2, 9 in the ectopic and eutopic endometrium with adenomyosis may be related with the pathologic mechanism ofadenomyosis