Solution and solid-phase synthesis of potent inhibitors of hepatitis C virus NS3 proteinase |
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| Authors: | Beevers Rebekah Carr Maria G Jones Philip S Jordan Steven Kay Paul B Lazell Robert C Raynham Tony M |
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| Affiliation: | Department of Chemistry, Roche Discovery Welwyn, 40 Broadwater Road, Welwyn Garden City, AL7 3AY, Hertfordshire, UK. |
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| Abstract: | A versatile route for the synthesis of homochiral alpha-ketoamide analogues of amino acids is described. Incorporation of this functionality into peptide sequences using either solution or solid-phase chemistry resulted in potent inhibitors of the Hepatitis C Virus NS3 proteinase. |
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