The effects of dopamine on temperature regulation in goldfish |
| |
Authors: | Lonnie P Wollmuth Larry I Crawshaw Hercules Panayiotides-Djaferis |
| |
Institution: | (1) Department of Biology and Environmental Science Program, Portland State University, 97207 Portland, Oregon, USA;(2) Present address: Department of Physiology and Biophysics, University of Washington, 98195 Seattle, Washington, USA |
| |
Abstract: | Summary Microinjections of dopamine (DA) were made into specific forebrain loci in goldfish (Carassius auratus: 40–85 g) to study the involvement of DA in behavioral thermoregulation. Injections of 25, 50, 100 and 250 ng DA into the anterior aspect of the nucleus preopticus periventricularis (NPP) led to consistent, dose-dependent decreases in selected temperature was observed following injections of 5 or 10 ng DA. Injections of the control solution were without effect.Injections of DA into other forebrain loci, including the posterior half of the NPP, either had no thermoregulatory effect or had minor thermoregulatory effects which, in comparison to injections into the most effective sites, were inconsistent and required larger doses to obtain. The decrease in selected temperature following injections of 100 ng DA into the anterior NPP was blocked by haloperidol, a dopaminergic antagonist, but not by phentolamine, a noradrenergic antagonist. Injections of haloperidol alone resulted in a minor, but statistically significant, increase in selected temperature.The most sensitive DA sites lie caudal to the sites most sensitive to norepinephrine within the anterior NPP. DA acts on the dopaminergic receptors of central thermoregulatory neurons in the anterior NPP of goldfish. These receptors appear to mediate behavioral responses to excessively warm environments.Abbreviations
DA
dopamine
-
NE
norepinephrine
-
NPP
nucleus preopticus periventricularis
-
PBS
phosphate buffer solution |
| |
Keywords: | Temperature selection Carassius auratus Dopamine Fish Behavioral thermoregulation |
本文献已被 SpringerLink 等数据库收录! |
|