The amyloid hypothesis for Alzheimer's disease: a critical reappraisal |
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| Authors: | John Hardy |
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| Affiliation: | Reta Lilla Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK |
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| Abstract: | The amyloid hypothesis has been the basis for most work on the pathogenesis of Alzheimer's disease. Recent clinical trials based on this hypothesis have been inconclusive. In this article I review the current status of the hypothesis and suggest that a major scientific need is to understand the normal function of amyloid-β precursor protein (APP) and think how this may relate to the cell death in the disease process. |
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| Keywords: | Alzheimer's disease amyloid congophilic angiopathy dementia pathogenesis tau |
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