TGF-beta expression during rat pregnancy and activity on decidual cell survival |
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| Authors: | Carl?Shooner Pierre-Luc?Caron Guylaine?Fréchette-Frigon Valérie?Leblanc Marie-Claude?Déry Email author" target="_blank">Eric?AsselinEmail author |
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| Institution: | 1.Département de Chimie-Biologie, Groupe de Recherche en Biopathologies Cellulaires et Moléculaires,Université du Québec à Trois-Rivières,C.P. 500,Trois-Rivières,Canada |
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| Abstract: | Background During early rat pregnancy, trophoblast of the tiny embryo joins with the endometrium and epithelial cells undergo apoptosis.
Near the end of pregnancy, regression of the decidua basalis (DB) is also observed (from day 14 to 20). However, little is
known about the intra-cellular and molecular mechanisms involved in apoptosis regulation in the uterus during pregnancy. The
objective of the present study was to investigate the presence and the developmental expression of transforming growth factor-beta
isoforms (TGF-beta well known differentiation factor) in the rat endometrium throughout pregnancy and its action in vitro
using cultured endometrial stromal cells. |
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