NO 与牙周病周期性发病关系的研究

目的：临床上牙周病总是活动与静止期交替发生，经研究牙周病患者中NO含量及其牙周病有显著相关性。本研究目的系为了阐明NO在牙周病中的调节机制。方法：通过对牙周炎患者不同时期的唾液NO含量进行分析，来检测其活动期与静止期NO含量变化。结论：数据表明，NO在高浓度状态下可以导致炎症加重，在低浓度状态下可以抗炎。

Study on Relationship between NO and Cyclic Disease Developmentof Patients with Periodontal Disease

Progression of periodontitis is characterized by periodic active phase and relative stationary phase alternately.Previous studies have shown that periodontal disease is closely associated with nitric oxide(NO).However,the relationship between the concentration of NO and the periodic progression of peodontal disease still remains unknown.It is hypothesized that NO may play a regulatory role in the development of periodontitis.In this study,the concentration of salivary NO from patients with periodontal disease were analyzed and compared between two groups of patient with active and stationary phases,respectively.The role and mechanism of NO in periodontal disease were delineated.Thus the result from this study will contribute to the treatment and prevention of periodontal disease.