Competition for electrons between mono-oxygenations of pyridine and 2-hydroxypyridine |
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Authors: | Chao Yang Yingxia Tang Hua Xu Ning Yan Naiyu Li Yongming Zhang Bruce E. Rittmann |
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Affiliation: | 1.Department of Environmental Science and Engineering, College of Life and Environmental Science,Shanghai Normal University,Shanghai,People’s Republic of China;2.Biodesign Swette Center for Environmental Biotechnology,Arizona State University,Tempe,USA |
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Abstract: | Pyridine and its heterocyclic derivatives are widely encountered in industrial wastewaters, and they are relatively recalcitrant to biodegradation. Pyridine biodegradation is initiated by two mono-oxygenation reactions that compete for intracellular electron donor (2H). In our experiments, UV photolysis of pyridine generated succinate, whose oxidation augmented the intracellular electron donor and accelerated pyridine biodegradation and mineralization. The first mono-oxygenation reaction always was faster than the second one, because electrons provided by intracellular electron donors were preferentially utilized by the first mono-oxygenase; this was true even when the concentration of 2HP was greater than the concentration of pyridine. In addition, the first mono-oxygenation had faster kinetics because it had higher affinity for its substrate (pyridine), along with less substrate self-inhibition. |
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