IGF-I regulates caveolin 1 and IRS1 interaction in caveolae |
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Authors: | Panetta Danilo Biedi Claudia Repetto Silvia Cordera Renzo Maggi Davide |
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Affiliation: | Department of Endocrinology and Metabolism, University of Genova, Genoa, Italy. |
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Abstract: | Caveolae are hot spots in IGF-I signalling as suggested by the facts that IGF-I receptors localize in caveolae, directly interact with and tyrosine phosphorylate caveolin 1, the major caveolar protein. Also a number of IGF-IR substrates reside in caveolae, supporting a role of these organelles in the regulation of IGF-I action. Recently, we have demonstrated that IGF-I could specifically regulate Shc phosphorylation in caveolae. Here we show that also IRS1 localizes in this region where it is tyrosine phosphorylated in the presence of IGF-I. Moreover, IRS1 co-immunoprecipitates with caveolin 1 and the specific phosphocaveolin 1-IRS1 interaction is increased by IGF-I. |
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Keywords: | IGF-I receptor IRS1 Caveolin 1 Tyrosine phosphorylation |
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