Oral vaccination of skunks with raccoon poxvirus recombinants expressing the rabies glycoprotein or the nucleoprotein. |
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| Authors: | M Fekadu J H Shaddock J W Sumner D W Sanderlin J C Knight J J Esposito G M Baer |
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| Institution: | Viral and Rickettsial Zoonoses Branch, Centers for Disease Control, Atlanta, Georgia 30333. |
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| Abstract: | Twenty nine skunks (Mephitis mephitis) were vaccinated orally with raccoon poxvirus (RCN) recombinants: 10 with a recombinant expressing the rabies virus glycoprotein (RCNRG), 10 with RCNRG mixed with a recombinant expressing the rabies virus nucleoprotein (RCNRN) and nine with RCN alone. Rabies virus neutralizing antibodies were detected in six of the 20 skunks; five skunks (three given RCNRG, two given a mixture of recombinants) survived a rabies challenge that was lethal for nine skunks vaccinated with RCN alone. |
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