Vasospasm is a significant factor in cyclosporine-induced neurotoxicity: Case report |
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| Authors: | Hilde MH Braakman Jan Lodder Alida A Postma Lambert FR Span Werner H Mess |
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| Institution: | (1) Department of Neurology, Maastricht University Medical Centre, Maastricht, the Netherlands;(2) Department of Radiology, Maastricht University Medical Centre, Maastricht, the Netherlands;(3) Department of Internal Medicine, Division of Haematology, Maastricht University Medical Centre, Maastricht, the Netherlands;(4) Department of Clinical Neurophysiology, Maastricht University Medical Centre, Maastricht, the Netherlands |
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| Abstract: | BackgroundThe aetiology of central nervous system lesions observed in cerebral cyclosporine neurotoxicity remains controversial.Case presentationWe report a 48-year-old woman with a non-severe aplastic anaemia who presented with stroke-like episodes while on cyclosporine treatment.Transcranial Doppler ultrasound revealed severely elevated flow velocities in several cerebral vessels, consistent with vasospasm. Immediately after reducing the cyclosporine dose, the stroke-like episodes disappeared. Only after cyclosporine withdrawal the transcranial Doppler ultrasound abnormalities fully resolved.ConclusionsThis case demonstrates a significant role of vasospasm in the pathway of cyclosporine-induced neurotoxicity. Transcranial Doppler ultrasound is an effective tool for the diagnosis and follow-up of cyclosporine-induced vasospasm. |
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