HELP (high efficiency liquid phase) new oligonucleotide synthesis on soluble polymeric support. |
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| Authors: | G M Bonora C L Scremin F P Colonna and A Garbesi |
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| Institution: | Department of Organic Chemistry, University of Padova, Italy. |
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| Abstract: | A simple, rapid and high-yielding method for the synthesis of oligonucleotides by the phosphotriesters approach is described. The use of polyethylene glycol (PEG) as soluble polymeric support preserves some convenient features of the solid-phase synthesis with new interesting advantages. Short oligonucleotides in hundred milligrams scale can be obtained from few grams of functionalized PEG. |
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