Depression of afferent arc of the in vivo cytotoxic T-cell immunity by bacterial lipopolysaccharides |
| |
| Authors: | K Mizoguchi I Nakashima Y Hasegawa K Isobe N Kato K Shimokata K Kawashima F Nagase K Ando T Yoshida |
| |
| Institution: | 1. Institute of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel;2. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;3. Department of Medicine H, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel;4. Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel;1. Texas A&M University College of Medicine, USA;2. Baylor Scott and White Health, USA;1. Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China;2. Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, Guizhou, China;3. School of Public Health, State University of New York at Albany, One University Place, Rensselaer, NY, USA;1. Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA, USA;2. Department of Urology, University of Iowa, Iowa City, IA, USA;3. Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, USA;4. Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA;5. Department of Mathematics, West Chester University, West Chester, PA, USA;6. Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA;7. Department of Preventative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;8. Department of Medicine David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA;9. Department of Urology, University of Michigan Ann Arbor, MI, USA;1. Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Av Roraima 1000, Prédio 20. Zip Code 97105-900 Santa Maria, RS, Brazil;2. Laboratório de Biogenômica Universidade Federal de Santa Maria, Av Roraima 1000, Prédio 19. Zip Code 97105-900 Santa Maria, RS, Brazil |
| |
| Abstract: | The afferent arc of the in vivo cytotoxic T-cell immunity assessed by second set rejection of ascitic allogeneic tumors was shown to be depressed by bacterial lipopolysaccharide (LPS) that was administered simultaneously with or 1 day before injection of allogeneic spleen cells as stimulators. Two different LPSs from Escherichia coli O55 and Klebsiella O3 displayed similar activities whereas dextran sulfate, concanavalin A, or poly A:U was not effective. Stimulator activities of allogeneic cells was not directly modified by LPS. Any definite suppressor activity on afferent or efferent arc of the T-cell response was not demonstrable in mice receiving LPS and allogeneic cells. Further, the LPS effect for immune depression was not diminished by whole body X-ray irradiation to the recipient at 300 R, which ablated the B-cell reactivity to LPS for polyclonal activation, or by treatment of the recipient with carrageenan, a known toxic agent to macrophages. It was suggested from these results that LPS suppresses the cytotoxic T-cell immunity by modulating responder T cells to be temporarily refractory to the allogeneic stimulus rather than by activating suppressor cells such as radiation-sensitive lymphocytes and carrageenan-sensitive macrophages. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
