Relative bioavailability and DNA adduct formation of benzo[a]pyrene and metabolites in the diet of the winter flounder. |
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| Authors: | A E McElroy J M Cahill J D Sisson K M Kleinow |
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| Institution: | Environmental Sciences Program, University of Massachusetts-Boston 02125. |
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| Abstract: | 1. Radiolabeled metabolites of the carcinogenic polycyclic aromatic hydrocarbon benzoa]pyrene (BaP) were shown to be absorbed through the diet of the winter flounder, Pseudopleuronectes americanus. 2. Oral bioavailability of a mixture of naturally produced metabolites was significantly less than that of the parent BaP. 3. Oral bioavailability of a pure metabolite, BaP-7,8-dihydrodiol (7,8-D) was found to be similar to that of BaP. 4. Both metabolites and BaP formed DNA adducts in liver. |
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