Chk1 phosphorylation during mitosis: A new role for a master regulator |
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| Authors: | Richard Chahwan Serge Gravel Takahiro Matsusaka Stephen P. Jackson |
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| Affiliation: | 1.The Gurdon Institute; University of Cambridge; Cambridge, UK;2.Department of Zoology; University of Cambridge; Cambridge, UK;3.Department of Biochemistry; University of Cambridge; Cambridge, UK |
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| Abstract: | The human DNA damage responses are modulated by both nonessential and essential pathways. The extensively studied ATM kinase and p53 are examples of the former. While loss-of-function mutations in genes that encode ATM and p53 cause marked predispositions to cancer, the loss of these proteins does not appear to impact basic cell growth and proliferation. In contrast, the checkpoint kinase Chk1 and its upstream activator ATR are essential.1-4 What do these proteins do in undamaged cells? |
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| Keywords: | cytokinesis Dma1 Dma2 E3 ubiquitin-ligase histone modification RNF8 Septins Septin-filament ubiquitin |
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