Anthrax,MEK and Cancer |
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| Authors: | Raghuveer Singh Mali Reuben Kapur |
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| Institution: | Department of Pediatrics; Indiana University School of Medicine; Indianapolis, IN USA |
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| Abstract: | The MEK family of protein kinases plays key roles in regulating cellular responses to mitogens as well as environmental stress. Inappropriate activation of these kinases contributes to tumorigenesis. In contrast, anthrax lethal factor, the principal virulence factor of anthrax toxin, has been demonstrated to selectively inactivate MEKs. In this article we will discuss recent advances in our understanding of molecular aspects of the pathogenesis of anthrax, emphasizing the potential role of MEK signalling in this disease, and outline novel strategies to use anthrax lethal toxin in the treatment of cancer. Key WordsAnthrax, MEK, MAPK, Cancer |
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| Keywords: | mast cells p85 regulatory subunits c-Kit PI3Kinase MITF differentiation survival |
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