The good,the bad and the ugly |
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Abstract: | VEGFC is a crucial player of lymphangiogenesis. Besides VEGFR2 and VEGFR3, it also binds NRP2. NRP2 enhances VEGFC/VEGFR3 effects in developmental lymphangiogenesis, but its role in adult and tumoral lymphangiogenesis is not known. In their study, Bagri and colleagues demonstrate that blocking NRP2 results in a decrease of metastasis formation, a phenomenon relying on tumoral lymphangiogenesis. Thus they identified NRP2 as an attractive new target for modulating metastasis. |
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