A new chronological survival assay in mammalian cell culture |
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Authors: | Zhaoyue He Hans-Uwe Simon |
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Affiliation: | Institute of Pharmacology; University of Bern; Bern, Switzerland |
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Abstract: | c-Abl is activated by oxidative stress but its precise function in cell response to this stress is elusive. Studies of c-Abl-/- osteoblasts revealed that c-Abl played a negative role in the induction of peroxiredoxin I (Prx I, Prdx I), an anti-oxidant protein with tumor suppression activity, but it provided a protective role against oxidative stress. In contrast, Atm, a signaling molecule that interacts with c-Abl and is required for c-Abl activation, served a totally different function. The significance of these findings is discussed here in the context of aging and tumorigenesis and their links to reactive oxygen species. |
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Keywords: | p53 ROS NCF2/p67phox NADPH oxidase NOX2 |
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