Xpd,a Structural Bridge and a Functional Link |
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Abstract: | Xpd, one of nine polypeptide subunits of the general transcriptionffactor TFIIH plays an organizing role in TFIIH assembly. This structural function in protein complex assembly appears to be used by cells in a dynamic way to regulate and co-ordinate the diverse cellular functions of the different sub-complexes in transcription, DNA repair and cell cycle progression. |
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