Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives |
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| Authors: | Li Wei Qiu Zaozao Wang Yibing Zhang Yichun Li Ming Yu Jia Zhang Lihong Zhu Ziyan Yu Biao |
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| Institution: | State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China. |
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| Abstract: | Dioscin derivatives (1-12) with a variety of substitutions at the 6'-OH of the chacotriosyl residue and the 3',6'-anhydrosaponin derivatives (26, 30, and 32) were synthesized. All these derivatives showed much lower cytotoxicity than that of the parent dioscin, while their hemolytic activities were partially retained depending on the various 6'-O-substitutions. |
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| Keywords: | Steroid saponins Synthesis Hemolytic activity Cytotoxicity Dioscin |
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