The phorbol ester TPA increases the affinity of exocytosis for calcium in ‘leaky’ adrenal medullary cells |
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Authors: | DE Knight PF Baker |
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Abstract: | Exposure of ‘leaky’ bovine adrenal medullary cells to the phorbol ester TPA causes a shift in the calcium-activation curve to lower calcium concentrations without altering the levels of secretion at the extremes of the activation curve. These results are consistent with a role for protein kinase C in exocytosis. |
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Keywords: | Calcium Exocytosis Secretion Catecholamine Phorbol ester Protein kinase C |
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