Missing genes in the annotation of prokaryotic genomes |
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Authors: | Andrew S Warren Jeremy Archuleta Wu-chun Feng João Carlos Setubal |
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Affiliation: | (1) Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA;(2) Department of Computer Science, Virginia Tech, Blacksburg, VA, USA |
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Abstract: | Background Protein-coding gene detection in prokaryotic genomes is considered a much simpler problem than in intron-containing eukaryotic genomes. However there have been reports that prokaryotic gene finder programs have problems with small genes (either over-predicting or under-predicting). Therefore the question arises as to whether current genome annotations have systematically missing, small genes. |
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