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Mammalian oocytes are targets for prostaglandin E2 (PGE2) action |
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| Authors: | Diane M Duffy Lynda K McGinnis Catherine A VandeVoort Lane K Christenson |
| Institution: | 1.Department of Physiological Sciences,Eastern Virginia Medical School,Norfolk,USA;2.Department of Molecular and Integrative Physiology,University of Kansas Medical Center,Kansas City,USA;3.California National Primate Research Center,University of California,Davis,USA;4.Department of Obstetrics and Gynecology,School of Medicine, University of California,Davis,USA |
| Abstract: | BackgroundThe ovulatory gonadotropin surge increases synthesis of prostaglandin E2 (PGE2) by the periovulatory follicle. PGE2 actions on granulosa cells are essential for successful ovulation. The aim of the present study is to determine if PGE2 also acts directly at the oocyte to regulate periovulatory events. |
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