Genetic islands of <Emphasis Type="Italic">Streptococcus agalactiae</Emphasis> strains NEM316 and 2603VR and their presence in other Group B Streptococcal strains |
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| Authors: | Email author" target="_blank">Mark?A?HerbertEmail author Catriona?JE?Beveridge David?McCormick Emmelien?Aten Nicola?Jones Lori?AS?Snyder Nigel?J?Saunders |
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| Institution: | (1) University Departments of Paediatrics, John Radcliffe Hospital Headington, OX3 9DU Oxford, UK;(2) Department of Microbiology, John Radcliffe Hospital Headington, OX3 9DU Oxford, UK;(3) Bacterial Pathogenesis and Functional Genomics Group, The Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, OX1 3RE Oxford, UK |
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| Abstract: | Background
Streptococcus agalactiae (Group B Streptococcus; GBS) is a major contributor to obstetric and neonatal bacterial sepsis. Serotype III strains cause
the majority of late-onset sepsis and meningitis in babies, and thus appear to have an enhanced invasive capacity compared
with the other serotypes that cause disease predominantly in immunocompromised pregnant women. We compared the serotype III
and V whole genome sequences, strains NEM316 and 2603VR respectively, in an attempt to identify genetic attributes of strain
NEM316 that might explain the propensity of strain NEM316 to cause late-onset disease in babies. Fourteen putative pathogenicity
islands were described in the strain NEM316 whole genome sequence. Using PCR- and targeted microarray- strategies, the presence
of these islands were assessed in a diverse strain collection including 18 colonizing isolates from healthy pregnant women,
and 13 and 8 invasive isolates from infants with early- and late-onset sepsis, respectively. |
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