Dietary omega-3 fatty acids and ionizing irradiation on human breast cancer xenograft growth and angiogenesis |
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Authors: | Email author" target="_blank">W?Elaine?HardmanEmail author LuZhe?Sun Nicholas?Short Ivan?L?Cameron |
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Institution: | (1) Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA;(2) University of Texas Health Science Center at San Antonio, Department of Cellular and Structural Biology, San Antonio, Texas 78229, USA |
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Abstract: | Background The effects of an omega-3 (n-3) fatty acid enriched diet alone and in combination with gamma irradiation (IR) therapy in nude
mice bearing a human MDA-MB231 breast cancer xenograft were tested. The cancer cells were injected into the mammary fat pad
of young female mice. Six weeks later, mice were randomly divided into two diet groups: 1) mice with 10% corn oil (rich in
omega 6 fatty acids) in their food, 2) mice consuming a 10% fat diet that was enriched in n-3 fatty acids. After two weeks
on the diet, treatment with 200 cGy of IR every second day for four treatments (total 800 cGy) was initiated on half of the
mice from each diet group. Some mice in each of the 4 groups were euthanized 24 hours after the end of IR while the remaining
mice were followed for 3 additional weeks. Tumor sections were stained for endothelial cells with CD31 and PAS and for hypoxia
inducible factor 1α (HIF-α). |
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Keywords: | |
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