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Synthesis of aminoazalactams as cyclic mimetics of basic alkyl amino acids |
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| Authors: | Roger E. Markwell Shahzad S. Rahman Robert W. Ward |
| Affiliation: | SmithKline Beecham Pharmaceuticals, Department of Medicinal Chemistry, Coldharbour Road, The Pinnacles, Harlow, Essex, CM19 5AD, UK |
| Abstract: | Novel medium ring conformationaly constrained amino acid derivatives 2 for incorporation into collagenase inhibitors were prepared, utilising natural amino acids as starting materials, via a reductive intramolecular imine cyclisation. |
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