AimTo develop a tool in order to guide pre-irradiation dental care (PIDC) for patients with oropharyngeal cancers.BackgroundOsteoradionecrosis of the jaws is a potential complication of radiotherapy (RT) for head and neck cancers. To prevent this complication, PIDC can involve multiple dental extractions as a preventative measure to avoid post-RT complications. However, there is no standardized tool to guide PIDC.Materials and methodsFrom January 2005 to October 2015, 120 head and neck cancer patients were prospectively included in a study investigating dysgeusia after RT. From this cohort, patients were enrolled according to the following inclusion criteria: histopathological confirmation of oropharyngeal squamous cell carcinoma; stage T1-4 N1-3 M0; ≤10 missing teeth. Individual teeth were retrospectively delineated on planning computed tomography and doses to dentition were assessed to generate templates.ResultsThirty-three patients were included. Molars received highest doses with a mean dose of 50?Gy (range; 19–75?Gy). Ipsi-lateral and contralateral wisdom teeth received RT dose superior to 50?Gy in 92% and 56% of cases, respectively. Patients with advanced disease (T4 or N2c-3) received higher mean doses on inferior and ipsi-lateral dental arches compared to other patients (T1-3 N0-2b): 42?Gy vs. 39?Gy and 44?Gy vs. 39?Gy (p?0.05), respectively.ConclusionPre-RT dose distribution templates are an objective way to prepare PIDC. Further studies with a larger cohort are needed to validate these templates. |