Application of induced pluripotency in cancer studies |
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Authors: | Patrycja Czerwińska Sylwia Mazurek Maciej Wiznerowicz |
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Institution: | 1. Laboratory of Gene Therapy, Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, Poznan, Poland;2. Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland;3. Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland |
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Abstract: | As soon as induced pluripotent stem cells (iPSCs) reprogramming of somatic cells were developed, the discovery attracted the attention of scientists, offering new perspectives for personalized medicine and providing a powerful platform for drug testing. The technology was almost immediately applied to cancer studies. As presented in this review, direct reprogramming of cancer cells with enforced expression of pluripotency factors have several basic purposes, all of which aim to explain the complex nature of cancer development and progression, therapy-resistance and relapse, and ultimately lead to the development of novel anti-cancer therapies. Here, we briefly present recent advances in reprogramming methodologies as well as commonalities between cell reprogramming and carcinogenesis and discuss recent outcomes from the implementation of induced pluripotency into cancer research. |
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Keywords: | CSC cancer stem cells iPSCs induced pluripotent stem cells iCSCs induced cancer stem-like cells SCNT somatic cell nuclear transfer Induced pluripotency Cancer reprogramming Cancer stem cells |
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