Adenosine and ATP: mutually exclusive modifiers of the kinetics of ADP-induced aggregation of calf-platelets |
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Authors: | M Jamaluddin L K Krishnan |
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Institution: | (1) Thrombosis Research Unit, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, 695 012 Trivandrum, India;(2) Present address: Department of Preventive Sciences, School of Dentistry, 55455 Minneapolis, MN, USA |
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Abstract: | Modulations of initial rate kinetics of ADP-induced aggregation of citrated calf platelet-rich plasma by adenosine and ATP
were investigated employing a spectrophotometric platelet aggregation assay. The data were analysed according to the tenets
of sequential shape-change and interaction model of aggregation. Adenosine and ATP increased the slopes and intercepts of
double-reciprocal plots of ADP-aggregation kinetics. Examination of their slope and intercept effects together with their
effects individually and in combination, on aggregation rates, suggested that adenosine and ATP acted at multiple, nonoverlapping,
sites. |
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Keywords: | Platelet aggregation kinetics ADP adenosine ATP (calf) |
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