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Stereospecific synthesis of new steroidal isoxazoles in dry media |
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| Authors: | Hernández-Linares María Guadalupe Sandoval-Ramírez Jesús Meza-Reyes Socorro Montiel-Smith Sara Guerrero-Luna Gabriel |
| Institution: | a Escuela de Ingeniería en Petróleos e Ingeniería Química, Universidad del Istmo, Ciudad Universitaria S/N, C.P. 70760 Sto. Domingo Tehuantepec, Oax., Mexico b Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Ciudad Universitaria, Col. San Manuel, C.P. 72570, Puebla, Pue., Mexico |
| Abstract: | An easy and fast procedure was developed for one-pot synthesis of steroidal isoxazoles starting from 23-acetylsapogenins derivatives in presence of P2O5/SiO2 in dry media under microwaves irradiation is described. Substrates of the 25S and 25R series were used as raw materials, establishing that this new methodology is applicable to both series. |
| Keywords: | 23-Acetylsapogenins Isoxazoles Steroidal heterocycles P2O5/SiO2 Microwaves |
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