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Differential Regulation of Carbon Partitioning by the Central Growth Regulator Target of Rapamycin (TOR)
摘    要:Target of rapamycin (TOR) is an evolutionary conserved ser- ine/threonine protein kinase found in yeast, plants, and ani- mals. TOR plays a central role in sensing nutrients and energy status, growth factors, and other environmental signals, and integrates these cues to synchronize cell growth-related pro- cesses (Laplante and Sabatini, 2012). In yeast and animal cells, TOR acts as the catalytic component in two structurally and functionally distinct protein complexes termed TORC (TOR complex) 1 and TORC2. TOR seems to be localized specifi- cally to the endomembrane system and the nucleus with a certain mobility, depending on the environmental conditions (Laplante and Sabatini, 2012). The three major components of TORCl, namely TOR, RAPTOR (Regulatory associated protein of mTOR), and LST8 (Lethal with Sec13 protein 8), are present in the genome of Arabidopsis, and interactions between TOR and RAPTOR, as well as TOR and LST8, occur also in plants, indicating the existence of a plant TORC1 (Moreau et al., 2012). Here, we highlight the possible role of TOR in carbon utilization and growth regulation in Arabidopsis.

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