盘基网柄菌——研究致病机制的宿主模型

盘基网柄菌作为致病菌宿主模型的研究主要有:筛选致病菌株及相应突变菌株毒性;鉴别对致病菌易感性和抗性的突变细胞宿主;宿主细胞的有效标记、已完成的基因组计划以及宿主细胞与致病菌间信号转导通路的相互作用;这些都表明盘基网柄菌是致病机制研究的理想宿主模型。

Dictyostelium discoideum as a Host Model in Pathogenesis Research

As a host model for pathogens, Dictyostelium discoideum has been studied in following fields: the use of Dictyostelium wild-type cells as screening system for virulence of pathogens and their corresponding mutants; the use of Dictyostelium mutant cells as identifying host susceptibility and resistance to infection; the availability of host cell markers, the completion of the genome project, and the interaction of signaling pathways between host and pathogens, which qualified Dictyostelium for the study of fundamental cellular processes of pathogenesis.